zoledronic acid 5 mg injection

Adult Dosing .

Dosage forms:  INJ

osteoporosis tx, postmenopausal

[5 mg IV q12mo]

Max: 5 mg/dose; Info: maintain adequate hydration prior to tx; avoid invasive dental procedure; calcium and vitamin D supplementation recommended if inadequate dietary intake; reassess need for tx in 3y; may consider drug holiday if stable after tx x3y (low-mod risk pt); optimal holiday duration up to 5y; if drug holiday initiated, reassess need for tx q2-4y and consider resuming tx in pts w/ fracture or significant BMD loss

osteoporosis prevention, postmenopausal

[5 mg IV q24mo]

Max: 5 mg/dose; Info: maintain adequate hydration prior to tx; avoid invasive dental procedure; calcium and vitamin D supplementation recommended if inadequate dietary intake

osteoporosis, male

[5 mg IV q12mo]

Max: 5 mg/dose; Info: maintain adequate hydration prior to tx; avoid invasive dental procedure; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; consider D/C after 3-5y in low-risk pts

osteoporosis, steroid-induced

[5 mg IV q12mo]

Max: 5 mg/dose; Info: for tx and prevention in pts on >7.5 mg/day prednisone or equiv; avoid invasive dental procedure; maintain adequate hydration prior to tx; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; consider D/C after 3-5y in low-risk pts

Paget bone dz

[5 mg IV x1]

Max: 5 mg/dose; Info: maintain adequate hydration prior to tx; avoid invasive dental procedure; give w/ calcium and vitamin D supplementation; consider retreatment if relapse

renal dosing

[see below]

CrCl <35: contraindicated; acute renal impairment: contraindicated

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

osteogenesis imperfecta (off-label)

[1 yo and older]

Dose: 0.05 mg/kg/dose IV q6mo; Max: 5 mg/dose; Info: maintain adequate hydration prior to tx; avoid invasive dental procedure; calcium and vitamin D supplementation recommended if inadequate dietary intake; periodically reassess need for tx; give for 1-4y

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance