Levonest

Adult Dosing .

Dosage forms:  triphasic pack

Special Note

[triphasic pack components]

Info: 28-day pack contains levonorgestrel/ethinyl estradiol 0.05 mg/30 mcg tab x6, then 0.075 mg/40 mcg tab x5, then 0.125 mg/30 mcg tab x10, then inert tab x7

[additional info]

Info: see Oral Contraceptive Pill (OCP) Therapeutic Equivalence and Oral Contraceptive Pill (OCP) Hormonal Activity tables

contraception

[1 tab PO qd]

Start: day 1 of menstrual cycle or 1st Sunday after onset of menses; Info: D/C >4wk before, restart >2wk after surgery w/ VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding

dysmenorrhea (off-label)

[1 tab PO qd]

Start: day 1 of menstrual cycle or 1st Sunday after onset of menses; Alt: 1 active tab PO qd x63-105 days, then 1 inert tab PO qd x7 days, then repeat cycle; Info: may skip inert tabs for continuous cycle if pain persists; D/C >4wk before, restart >2wk after surgery w/ VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding

emergency contraception (off-label)

[4 tabs PO q12h x2 doses]

Start: ASAP after unprotected intercourse; maximum efficacy w/in 72h, moderate efficacy w/in 120h; Info: use light brown tabs (levonorgestrel/ethinyl estradiol 0.125 mg/30 mcg); repeat dose if vomiting occurs w/in 3h

endometriosis (off-label)

[1 tab PO qd]

Start: day 1 of menstrual cycle or 1st Sunday after onset of menses; Alt: 1 active tab PO qd x63-105 days, then 1 inert tab PO qd x7 days, then repeat cycle; Info: may skip inert tabs for continuous cycle if pain persists; D/C >4wk before, restart >2wk after surgery w/ VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding

renal dosing

[see below]

renal dz: not defined, caution advised

HD/PD: avoid use

hepatic dosing

[see below]

active hepatic dz: contraindicated

Peds Dosing .

Dosage forms:  triphasic pack

Special Note

[triphasic pack components]

Info: 28-day pack contains levonorgestrel/ethinyl estradiol 0.05 mg/30 mcg tab x6, then 0.075 mg/40 mcg tab x5, then 0.125 mg/30 mcg tab x10, then inert tab x7

[additional info]

Info: see Oral Contraceptive Pill (OCP) Therapeutic Equivalence and Oral Contraceptive Pill (OCP) Hormonal Activity tables

contraception

[postmenarchal females]

Dose: 1 tab PO qd; Start: day 1 of menstrual cycle or 1st Sunday after onset of menses; Info: D/C >4wk before, restart >2wk after surgery w/ VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding

dysmenorrhea (off-label)

[postmenarchal females]

Dose: 1 tab PO qd; Start: day 1 of menstrual cycle or 1st Sunday after onset of menses; Alt: 1 active tab PO qd x63-105 days, then 1 inert tab PO qd x7 days, then repeat cycle; Info: may skip inert tabs for continuous cycle if pain persists; D/C >4wk before, restart >2wk after surgery w/ VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding

emergency contraception (off-label)

[postmenarchal females]

Dose: 4 tabs PO q12h x2 doses; Start: ASAP after unprotected intercourse; maximum efficacy w/in 72h, moderate efficacy w/in 120h; Info: use light brown tabs (levonorgestrel/ethinyl estradiol 0.125 mg/30 mcg); repeat dose if vomiting occurs w/in 3h

endometriosis (off-label)

[postmenarchal females]

Dose: 1 tab PO qd; Start: day 1 of menstrual cycle or 1st Sunday after onset of menses; Alt: 1 active tab PO qd x63-105 days, then 1 inert tab PO qd x7 days, then repeat cycle; Info: may skip inert tabs for continuous cycle if pain persists; D/C >4wk before, restart >2wk after surgery w/ VTE risk; restart >4wk postpartum or >6wk postpartum if breastfeeding

renal dosing

[see below]

renal dz: not defined, caution advised

HD/PD: avoid use

hepatic dosing

[see below]

active hepatic dz: contraindicated