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Black Box Warnings .
Hepatotoxicity
acetaminophen assoc. w/ acute liver failure incl. cases of liver transplant and death; most liver injury assoc. w/ acetaminophen doses >4000 mg per day and >1 acetaminophen-containing product
Adult Dosing .
Dosage forms: CAP: 50 mg/325 mg/40 mg; TAB: 50 mg/325 mg/40 mg
tension-type headache
- [1-2 caps/tabs PO q4h prn]
- Max: 6 caps or tabs/day; 4 g/day acetaminophen from all sources; Info: taper dose gradually to D/C if long-term use
renal dosing
- [see below]
- CrCl 10-50: give usual dose q6h prn; CrCl <10: give usual dose q8h prn; Info: max 6 caps or tabs/day
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose
Peds Dosing .
- Dosage forms: CAP: 50 mg/325 mg/40 mg; TAB: 50 mg/325 mg/40 mg
tension-type headache
- [12 yo and older]
- Dose: 1-2 caps/tabs PO q4h prn; Max: 6 caps or tabs/day; 4 g/day acetaminophen from all sources; Info: taper dose gradually to D/C if long-term use
renal dosing
- [see below]
- CrCl 10-50: give usual dose q6h prn; CrCl <10: give usual dose q8h prn; Info: max 6 caps or tabs/day
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose