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quinidine gluconate
generic
Black Box Warnings .
Mortality
incr. mortality in tx of non-life-threatening arrhythmias, incr. risk if structural heart dz; quinidine sulfate mortality more than 3x placebo rate when used to prevent/defer atrial fib/flutter recurrence; higher quinidine-assoc. mortality in non-life-threatening ventricular arrhythmias vs. various other antiarrhythmics
Adult Dosing .
Dosage forms: ER TAB: 324 mg
atrial fibrillation/flutter
- [cardioversion]
- Dose: 648 mg PO q8h x3-4 doses, then incr. dose q8h as tolerated until sinus rhythm; Alt: 324 mg PO q8h x2 days, then 648 mg PO q12h x2 days, then 648 mg PO q8h for up to 4 days; Info: tab may be cut in half, but do not crush/chew; see pkg insert for D/C criteria based on ECG, BP
- [maintenance rate control]
- Dose: 324-648 mg PO q8h; Start: 324 mg PO q8-12h; Info: adjust dose based on serum levels; tab may be cut in half, but do not crush/chew; see pkg insert for dose adjustment criteria based on ECG, BP
ventricular arrhythmias
- [324-648 mg PO q8h]
- Start: 324 mg PO q8-12h; Info: adjust dose based on serum levels; tab may be cut in half, but do not crush/chew; see pkg insert for dose adjustment criteria based on ECG, BP
renal dosing
- [adjust dose amount]
- CrCl <10: decr. usual dose by 25%
- HD: decr. usual dose by 25%; no supplement after dialysis; PD: decr. usual dose by 25%; no supplement
hepatic dosing
- [see below]
- hepatic impairment: consider decr. usual dose
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.