Avycaz

Adult Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total ceftazidime + avibactam amt; 2.5 g ceftazidime/avibactam contains 2 g ceftazidime + 0.5 g avibactam

intra-abdominal infections, complicated

[2.5 g IV q8h x5-14 days]

Info: give w/ metronidazole 500 mg PO/IV q6-8h; duration varies by infection site/severity

UTI, complicated

[2.5 g IV q8h x7-14 days]

Info: duration varies by infection severity

pneumonia, hospital-acquired or ventilator-assoc.

[2.5 g IV q8h x7 days]

Info: may extend duration based on clinical response; refer to IDSA guidelines

renal dosing

[see below]

CrCl 31-50: 1.25 g q8h; CrCl 16-30: 0.94 g q12h; CrCl 6-15: 0.94 g q24h; CrCl <6: 0.94 g q48h

HD: 0.94 g q48h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total ceftazidime + avibactam amt; 2.5 g ceftazidime/avibactam contains 2 g ceftazidime + 0.5 g avibactam

intra-abdominal infections, complicated

[31 wk gestation and older, <29 days old]

Dose: 25 mg/kg/dose IV q8h x5-14 days; Info: give w/ metronidazole 30 mg/kg/day IV divided q6-8h; duration varies by infection site/severity

[29 days old-2 mo]

Dose: 37.5 mg/kg/dose IV q8h x5-14 days; Info: give w/ metronidazole 30 mg/kg/day IV divided q6-8h; duration varies by infection site/severity

[3-5 mo]

Dose: 50 mg/kg/dose IV q8h x5-14 days; Info: give w/ metronidazole 30 mg/kg/day IV divided q6-8h; duration varies by infection site/severity

[6 mo-1 yo]

Dose: 62.5 mg/kg/dose IV q8h x5-14 days; Info: give w/ metronidazole 30 mg/kg/day IV divided q6-8h; duration varies by infection site/severity

[2 yo and older]

Dose: 62.5 mg/kg/dose IV q8h x5-14 days; Max: 2.5 g/dose; Info: give w/ metronidazole 30 mg/kg/day IV divided q6-8h; duration varies by infection site/severity

UTI, complicated

[31 wk gestation and older, <29 days old]

Dose: 25 mg/kg/dose IV q8h x7-14 days; Info: duration varies by infection site/severity

[29 days old-2 mo]

Dose: 37.5 mg/kg/dose IV q8h x7-14 days; Info: duration varies by infection site/severity

[3-5 mo]

Dose: 50 mg/kg/dose IV q8h x7-14 days; Info: duration varies by infection severity

[6 mo-1 yo]

Dose: 62.5 mg/kg/dose IV q8h x7-14 days; Info: duration varies by infection severity

[2 yo and older]

Dose: 62.5 mg/kg/dose IV q8h x7-14 days; Max: 2.5 g/dose; Info: duration varies by infection severity

pneumonia, hospital-acquired or ventilator-assoc.

[31 wk gestation and older, <29 days old]

Dose: 25 mg/kg/dose IV q8h x7-14 days

[29 days old-2 mo]

Dose: 37.5 mg/kg/dose IV q8h x7-14 days

[3-5 mo]

Dose: 50 mg/kg/dose IV q8h x7-14 days

[6 mo-1 yo]

Dose: 62.5 mg/kg/dose IV q8h x7-14 days

[2 yo and older]

Dose: 62.5 mg/kg/dose IV q8h x7-14 days; Max: 2.5 g/dose

renal dosing

[<2 yo]

renal impairment: not defined

HD/PD: not defined

[2 yo and older]

CrCl 31-50: 31.25 mg/kg/dose q8h, max 1.25 g/dose; CrCl 16-30: 23.75 mg/kg/dose q12h, max 0.94 g/dose; CrCl 6-15: 23.75 mg/kg/dose q24h, max 0.94 g/dose; CrCl <6: 23.75 mg/kg/dose q48h, max 0.94 g/dose

HD: 23.75 mg/kg/dose q48h, max 0.94 g/dose, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

hepatic dosing

[no adjustment]