Corlanor

Adult Dosing .

Dosage forms:  TAB: 5 mg, 7.5 mg; SOL: 1 mg per mL

heart failure w/ reduced ejection fraction, NYHA Class II-III

[2.5-7.5 mg PO bid]

Start: 5 mg PO bid x2wk, then may adjust dose by 5 mg/day to maintain resting HR 50-60; Max: 15 mg/day; Info: for pts on max tolerated beta blockers w/ LVEF 35% or lower and resting HR at least 70; start 2.5 mg PO bid in pts w/ conduction defect hx or hemodynamic compromise risk; D/C if resting HR <50 or s/sx bradycardia on 2.5 mg PO bid; give w/ meals

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: contraindicated

Peds Dosing .

Dosage forms:  TAB: 5 mg, 7.5 mg; SOL: 1 mg per mL

heart failure, dilated cardiomyopathy-associated

[6-11 mo, <40 kg]

Dose: 0.05-0.2 mg/kg/dose PO bid; Start: 0.05 mg/kg/dose PO bid, then may adjust dose by 0.1 mg/kg/day q2wk to target HR decr. by at least 20% as tolerated; Max: 0.4 mg/kg/day up to 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; if bradycardia on initial start dose, consider decr. to 0.02 mg/kg/dose PO bid; give w/ meals

[1 yo and older, <40 kg]

Dose: 0.05-0.3 mg/kg/dose PO bid; Start: 0.05 mg/kg/dose PO bid, then may adjust dose by 0.1 mg/kg/day q2wk to target HR decr. by at least 20% as tolerated; Max: 0.6 mg/kg/day up to 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; if bradycardia on initial start dose, consider decr. to 0.02 mg/kg/dose PO bid; give w/ meals

[6 mo and older, >40 kg]

Dose: 2.5-7.5 mg PO bid; Start: 2.5 mg PO bid, then may adjust dose by 5 mg/day q2wk to target HR decr. by at least 20% as tolerated; Max: 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; if bradycardia on initial start dose, consider decr. to 0.02 mg/kg/dose PO bid; give w/ meals

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: contraindicated