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Prestalia
perindopril arginine/ amlodipine
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 3.5 mg/2.5 mg, 7 mg/5 mg, 14 mg/10 mg
HTN
- [1 tab PO qd]
- Start: 3.5 mg/2.5 mg PO qd, may incr. dose q7-14 days; Max: 14 mg/10 mg/day
renal dosing
- [see below]
- CrCl 30-80: max 7 mg/5 mg/day; CrCl <30: avoid use
- HD: max 7 mg/5 mg/day, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.