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Invega Trinza
paliperidone palmitate
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 273 mg per 0.875 mL, 410 mg per 1.315 mL, 546 mg per 1.75 mL, 819 mg per 2.625 mL
schizophrenia
- [conversion from paliperidone palmitate 78 mg/mo IM]
- Dose: 273 mg IM q3mo; Start: at next scheduled dose after at least 4mo tx w/ 1-mo IM paliperidone palmitate form (last 2 doses same strength); Max: 819 mg/dose; Info: may adjust dose q3mo; see pkg insert for missed dose recommendations and conversion to oral paliperidone; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from paliperidone palmitate 117 mg/mo IM]
- Dose: 410 mg IM q3mo; Start: at next scheduled dose after at least 4mo tx w/ 1-mo IM paliperidone palmitate form (last 2 doses same strength); Max: 819 mg/dose; Info: may adjust dose q3mo; see pkg insert for missed dose recommendations and conversion to oral paliperidone; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from paliperidone palmitate 156 mg/mo IM]
- Dose: 546 mg IM q3mo; Start: at next scheduled dose after at least 4mo tx w/ 1-mo IM paliperidone palmitate form (last 2 doses same strength); Max: 819 mg/dose; Info: may adjust dose q3mo; see pkg insert for missed dose recommendations and conversion to oral paliperidone; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
- [conversion from paliperidone palmitate 234 mg/mo IM]
- Dose: 819 mg IM q3mo; Start: at next scheduled dose after at least 4mo tx w/ 1-mo IM paliperidone palmitate form (last 2 doses same strength); Max: 819 mg/dose; Info: may adjust dose q3mo; see pkg insert for missed dose recommendations and conversion to oral paliperidone; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
renal dosing
- [see below]
- CrCl 50-79: adjust dose using 1-mo IM paliperidone palmitate form prior to conversion; CrCl <50: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.