Select a medication above to begin.
Rexulti
brexpiprazole
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis w/o agitation associated w/ dementia due to Alzheimer dz; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Suicidality
incr. suicidality risk in peds and young adult pts in short-term studies; observe all antidepressant-treated pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for depression in peds pts
Adult Dosing .
Dosage forms: TAB: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg
major depressive disorder, adjunct tx
- [2 mg PO qd]
- Start: 0.5-1 mg PO qd, may incr. dose qwk; Max: 3 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx
schizophrenia
- [2-4 mg PO qd]
- Start: 1 mg PO qd x4 days, then 2 mg PO qd x3 days, then may incr. to 4 mg PO qd; Max: 4 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx
dementia-associated agitation, pts w/ Alzheimer dz
- [2 mg PO qd]
- Start: 0.5 mg PO qd x7 days, then 1 mg PO qd x7 days, then 2 mg PO qd, then may incr. to 3 mg PO qd after at least 14 days; Max: 3 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx
renal dosing
- [schizophrenia]
- CrCl <60: max 3 mg/day
- HD/PD: not defined
- [all other indications]
- CrCl <60: max 2 mg/day
- HD/PD: not defined
hepatic dosing
- [schizophrenia]
- Child-Pugh Class B or C: max 3 mg/day
- [all other indications]
- Child-Pugh Class B or C: max 2 mg/day
Peds Dosing .
- Dosage forms: TAB: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg
schizophrenia
- [13-17 yo]
- Dose: 2-4 mg PO qd; Start: 0.5 mg PO qd x4 days, then 1 mg PO qd x3 days, then may incr. to 2 mg PO qd, then may incr. by 1 mg/day qwk; Max: 4 mg/day; Info: decr. dose 50% in CYP2D6 poor metabolizers; periodically reassess need for tx
renal dosing
- [adjust dose amount]
- CrCl <60: max 3 mg/day
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B or C: max 3 mg/day