Repatha

Adult Dosing .

Dosage forms:  INJ (SureClick auto-injector): 140 mg; INJ (pre-filled syringe): 140 mg per mL

cardiovascular event risk reduction

[140 mg SC q2wk]

Alt: 420 mg SC qmo; Info: for pts w/ established CVD

primary hyperlipidemia

[140 mg SC q2wk]

Alt: 420 mg SC qmo

heterozygous familial hypercholesterolemia

[140 mg SC q2wk]

Alt: 420 mg SC qmo

homozygous familial hypercholesterolemia, adjunct tx

[420 mg SC qmo or 420 mg SC q2wk]

Start: 420 mg SC qmo, may incr. to 420 mg SC q2wk after 12wk if inadequate response; Info: may start 420 mg SC q2wk if pt on lipid apheresis

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Dosage forms:  INJ (SureClick auto-injector): 140 mg; INJ (pre-filled syringe): 140 mg per mL

heterozygous familial hypercholesterolemia, adjunct tx

[10 yo and older]

Dose: 140 mg SC q2wk; Alt: 420 mg SC qmo

homozygous familial hypercholesterolemia, adjunct tx

[10 yo and older]

Dose: 420 mg SC qmo or 420 mg SC q2wk; Start: 420 mg SC qmo, may incr. to 420 mg SC q2wk after 12wk if inadequate response; Info: may start 420 mg SC q2wk if pt on lipid apheresis

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined