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Odomzo
sonidegib
Black Box Warnings .
Embryo-Fetal Toxicity
embryotoxic, fetotoxic, and teratogenic in animals, incl. embryo-fetal death or severe birth defects; verify pregnancy status prior to tx start; advise female pts of need for contraception during and for at least 20mo after D/C; advise male pts of potential exposure risk via semen and need for condom use during and for at least 8mo after D/C
Adult Dosing .
Dosage forms: CAP: 200 mg
Restricted Distribution in US
- [1-844-563-6696 or www.odomzo.com for more info]
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
basal cell CA, locally advanced
- [200 mg PO qd]
- Info: give at least 1h before or 2h after meals
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.