quinine sulfate

Adult Dosing .

Dosage forms:  CAP: 324 mg

Special Note

[strength clarification]

Info: 650 mg quinine sulfate = 542 mg quinine base; doses expressed as quinine sulfate

malaria, uncomplicated

[2 caps PO q8h x3 days]

Info: give w/ doxycycline, tetracycline, or clindamycin; if P. falciparum infection acquired in Southeast Asia, give x7 days; give w/ food; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

babesiosis (off-label)

[2 caps PO q6-8h x7-10 days]

Info: give w/ clindamycin; not 1st-line regimen; tx for at least 6wk if immunocompromised; give w/ food

renal dosing

[malaria]

mild-moderate renal impairment: not defined; severe chronic renal impairment: 2 caps x1, then 1 cap q12h

HD: 2 caps q24h, on dialysis days admin. after dialysis; no supplement; PD: 2 caps q24h; no supplement

[babesiosis]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: avoid use

Peds Dosing .

Dosage forms:  CAP: 324 mg

Special Note

[strength clarification]

Info: 10 mg/kg quinine sulfate = 8.3 mg/kg quinine base; doses expressed as quinine sulfate

malaria, uncomplicated (off-label)

[30 mg/kg/day PO divided q8h x3 days]

Max: 2 caps/dose; Info: give w/ doxycycline, tetracycline, or clindamycin; if P. falciparum infection acquired in Southeast Asia, give x7 days; give w/ food; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

babesiosis (off-label)

[8 mg/kg/dose PO q6-8h x7-10 days]

Max: 2 caps/dose; Info: give w/ clindamycin; not 1st-line regimen; tx for at least 6wk if immunocompromised; give w/ food

renal dosing

[malaria]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

[babesiosis]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: avoid use