Aristada

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 441 mg per 1.6 mL, 662 mg per 2.4 mL, 882 mg per 3.2 mL, 1064 mg per 3.9 mL

Special Note

[formulation clarification]

Info: Aristada not interchangeable w/ Aristada Initio due to different pharmacokinetic profiles

schizophrenia

[qmo dosing regimen]

Dose: 441-882 mg IM qmo; Start: may give 1st dose w/in 10 days of concurrent Aristada Initio and aripiprazole 30 mg PO x1, otherwise overlap PO aripiprazole x21 days; Info: for pts stable on PO aripiprazole; see pkg insert for conversion from PO aripiprazole and for missed dose recommendations; space doses at least 14 days apart; decr. dose in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[q6wk dosing regimen]

Dose: 882 mg IM q6wk; Start: may give 1st dose w/in 10 days of concurrent Aristada Initio and aripiprazole 30 mg PO x1, otherwise overlap PO aripiprazole x21 days; Info: for pts stable on PO aripiprazole; see pkg insert for conversion from PO aripiprazole and for missed dose recommendations; space doses at least 14 days apart; decr. dose in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

[q2mo dosing regimen]

Dose: 1064 mg IM q2mo; Start: may give 1st dose w/in 10 days of concurrent Aristada Initio and aripiprazole 30 mg PO x1, otherwise overlap PO aripiprazole x21 days; Info: for pts stable on PO aripiprazole; see pkg insert for conversion from PO aripiprazole and for missed dose recommendations; space doses at least 14 days apart; decr. dose in CYP2D6 poor metabolizers; periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.