insulin degludec

Adult Dosing .

Dosage forms:  INJ (U-100 vial): 100 units per mL; INJ (FlexTouch U-100 pen): 100 units per mL; INJ (FlexTouch U-200 pen): 200 units per mL

Special Note

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[individualize dose SC qd]

Start: approx. 33-50% of total daily insulin requirement, may incr. dose q3-4 days; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); use w/ rapid-acting or short-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 1h, no true peak, duration up to 42h (long-acting basal insulin)

diabetes mellitus, type 2

[individualize dose SC qd]

Start: 10 units SC qd, may incr. dose q3-4 days; Info: dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 1h, no true peak, duration up to 42h (long-acting basal insulin)

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD/PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ (U-100 vial): 100 units per mL; INJ (FlexTouch U-100 pen): 100 units per mL; INJ (FlexTouch U-200 pen): 200 units per mL

Special Note

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[insulin-naive pts, 1 yo and older]

Dose: individualize dose SC qd; Start: approx. 33-50% of total daily insulin requirement, may incr. dose q3-4 days; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; use w/ rapid-acting or short-acting insulin; onset 1h, no true peak, duration up to 42h (long-acting basal insulin)

[insulin-experienced pts, 1 yo and older]

Dose: individualize dose SC qd; Start: 80% of current total daily basal insulin dose, may incr. dose q3-4 days; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; use w/ rapid-acting or short-acting insulin; onset 1h, no true peak, duration up to 42h (long-acting basal insulin)

diabetes mellitus, type 2

[insulin-naive pts, 1 yo and older]

Dose: individualize dose SC qd; Start: 10 units SC qd, may incr. dose q3-4 days; Info: onset 1h, no true peak, duration up to 42h (long-acting basal insulin)

[insulin-experienced pts, 1 yo and older]

Dose: individualize dose SC qd; Start: 80% of current total daily basal insulin dose, may incr. dose q3-4 days; Info: onset 1h, no true peak, duration up to 42h (long-acting basal insulin)

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD/PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised