Tagrisso

Adult Dosing .

Dosage forms:  TAB: 40 mg, 80 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

non-small cell lung CA

[adjuvant tx, monotherapy]

Dose: 80 mg PO qd for up to 3y; Start: after tumor resection; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations

[locally advanced, stage III unresectable dz, monotherapy]

Dose: 80 mg PO qd; Start: after platinum-based chemoradiation; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations w/o dz progression on or after platinum-based chemoradiation

[metastatic dz, first-line tx, monotherapy]

Dose: 80 mg PO qd; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations

[locally advanced or metastatic dz, first-line tx, combo tx]

Dose: 80 mg PO qd; Info: for pts w/ EGFR exon 19 deletions or exon 21 (L858R) substitution mutations; part of multi-drug chemo regimen

[progressive metastatic dz, monotherapy]

Dose: 80 mg PO qd; Info: for pts w/ EGFR T790M mutations

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.