Nucala

Adult Dosing .

Dosage forms:  INJ (auto-injector): 100 mg; INJ (pre-filled syringe): 100 mg per mL; INJ (vial): 100 mg per mL

severe asthma, maintenance tx

[100 mg SC q4wk]

Info: for add-on tx in pts w/ eosinophilic phenotype; consider varicella vaccine before tx start if herpes zoster risk

eosinophilic granulomatosis w/ polyangiitis

[300 mg SC q4wk]

Info: consider varicella vaccine before tx start if herpes zoster risk

hypereosinophilic syndrome

[300 mg SC q4wk]

Info: for pts w/ dz for at least 6mo w/o identifiable non-hematologic secondary cause; consider varicella vaccine before tx start if herpes zoster risk

chronic rhinosinusitis w/ nasal polyps, adjunct tx

[100 mg SC q4wk]

Info: consider varicella vaccine before tx start if herpes zoster risk

renal dosing

[see below]

CrCl >50: no adjustment; CrCl <50: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (auto-injector): 100 mg; INJ (pre-filled syringe): 40 mg per 0.4 mL; 100 mg per mL; INJ (vial): 100 mg per mL

severe asthma, maintenance tx

[6-11 yo]

Dose: 40 mg SC q4wk; Info: for add-on tx in pts w/ eosinophilic phenotype; consider varicella vaccine before tx start if herpes zoster risk

[12 yo and older]

Dose: 100 mg SC q4wk; Info: for add-on tx in pts w/ eosinophilic phenotype; consider varicella vaccine before tx start if herpes zoster risk

hypereosinophilic syndrome

[12 yo and older]

Dose: 300 mg SC q4wk; Info: for pts w/ dz for at least 6mo w/o identifiable non-hematologic secondary cause; consider varicella vaccine before tx start if herpes zoster risk

renal dosing

[see below]

CrCl >50: no adjustment; CrCl <50: not defined

HD/PD: not defined

hepatic dosing

[not defined]