Select a medication above to begin.
felbamate
generic
Black Box Warnings .
Aplastic Anemia
incidence may be >100x that of untreated population; only for severe epilepsy where tx benefits outweigh risk; consider hematologic consult prior to/during tx; risk of death varies w/ severity and etiology; overall case fatality rate 20-30%; bone marrow injury occurs prior to clinical manifestation, thus aplastic anemia may occur after D/C tx; unknown if risk affected by dose, duration, or concomitant drugs; D/C if any evidence bone marrow depression
Hepatic Failure
acute hepatic failure reported, incl. fatal; only for severe epilepsy where tx benefits outweigh risk; unknown if risk affected by dose, duration, or concomitant drugs; do not use if hepatic impairment hx; monitor LFTs at baseline, then periodically; D/C tx if LFTs >2x ULN or clinical s/sx of hepatic failure
Adult Dosing .
Dosage forms: TAB: 400 mg, 600 mg; SUSP: 600 mg per 5 mL
Special Note
- [prescribing info]
- Info: prescriber and pt must sign risk acknowledgment form
seizure disorder
- [monotherapy]
- Dose: 2400-3600 mg/day PO divided tid-qid; Start: 1200 mg/day PO divided tid-qid, incr. by 600 mg/day q2wk if initial tx or by 1200 mg/day qwk if switching from other anti-seizure meds; Max: 3600 mg/day; Info: taper dose gradually to D/C
- [adjunct tx]
- Dose: 2400-3600 mg/day PO divided tid-qid; Start: 1200 mg/day PO divided tid-qid, incr. by 1200 mg/day qwk; Max: 3600 mg/day; Info: taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- renal impairment: decr. usual dose by 50%
- HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement
hepatic dosing
- [see below]
- hepatic impairment hx: contraindicated
Peds Dosing .
- Dosage forms: TAB: 400 mg, 600 mg; SUSP: 600 mg per 5 mL
Special Note
- [prescribing info]
- Info: prescriber and parent/guardian must sign risk acknowledgment form
seizures, Lennox-Gastaut syndrome
- [adjunct tx, 2-14 yo]
- Dose: 45 mg/kg/day PO divided tid-qid; Start: 15 mg/kg/day PO divided tid-qid, incr. by 15 mg/kg/day qwk; Max: 45 mg/kg/day up to 3600 mg/day; Info: taper dose gradually to D/C
seizure disorder
- [monotherapy, 14 yo and older]
- Dose: 2400-3600 mg/day PO divided tid-qid; Start: 1200 mg/day PO divided tid-qid, incr. by 600 mg/day q2wk if initial tx or by 1200 mg/day qwk if switching from other anti-seizure meds; Max: 3600 mg/day; Info: taper dose gradually to D/C
- [adjunct tx, 14 yo and older]
- Dose: 2400-3600 mg/day PO divided tid-qid; Start: 1200 mg/day PO divided tid-qid, incr. by 1200 mg/day qwk; Max: 3600 mg/day; Info: taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- renal impairment: decr. usual dose by 50%
- HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement
hepatic dosing
- [see below]
- hepatic impairment hx: contraindicated