letrozole

Adult Dosing .

Dosage forms:  TAB: 2.5 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

breast CA, postmenopausal

[hormone receptor-positive early dz, adjuvant tx]

Dose: 2.5 mg PO qd; Info: also for extended adjuvant tx after 5y tamoxifen tx

[locally advanced or metastatic dz]

Dose: 2.5 mg PO qd

[advanced, progressive dz]

Dose: 2.5 mg PO qd

ovulation induction (off-label)

[2.5-5 mg PO qd x5 days]

Start: day 3 of menstrual cycle

renal dosing

[see below]

CrCl >10: no adjustment; CrCl <10: not defined

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[adjust dose frequency]

cirrhosis/Child-Pugh Class C: give usual dose q48h

Peds Dosing .

Dosage forms:  TAB: 2.5 mg

precocious puberty (off-label)

[2 yo and older]

Dose: 2.5 mg PO qd; Info: for female pts w/ McCune-Albright syndrome or male pts w/ testotoxicosis

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance