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Envarsus XR
tacrolimus
Black Box Warnings .
Malignancies and Serious Infections
incr. risk of serious infections and malignancies in pts receiving immunosuppressants may lead to hospitalization or death
Adult Dosing .
Dosage forms: ER TAB: 0.75 mg, 1 mg, 4 mg
Special Note
- [formulation clarification]
- Info: tacrolimus ER products not interchangeable w/ other ER or IR products; do not substitute on a mg to mg basis
kidney transplant rejection prophylaxis
- [de novo transplant pts]
- Dose: 0.14 mg/kg/dose PO qam; Info: adjust dose based on serum levels; give on empty stomach; do not cut/crush/chew tab
- [pts converting from IR formulations]
- Dose: individualize dose PO qam; Start: approx. 80% of total daily IR tacrolimus dose; Info: adjust dose based on serum levels; give on empty stomach; do not cut/crush/chew tab
renal dosing
- [see below]
- renal impairment: give lowest recommended dose, may consider further dose decr.
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate impairment: not defined; severe impairment: consider decr. usual dose
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.