Uptravi

Adult Dosing .

Dosage forms:  TAB: 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1000 mcg, 1200 mcg, 1400 mcg, 1600 mcg; INJ: 1800 mcg

Restricted Distribution in US

[1-866-228-3546 or www.uptravi.com for more info]

pulmonary arterial HTN

[200-1600 mcg PO bid]

Start: 200 mcg PO bid, may incr. by 400 mcg/day PO qwk as tolerated; Max: 3200 mcg/day PO; 3600 mcg/day IV; Alt: 225-1800 mcg IV bid; Info: may use IV temporarily if unable to take PO; see pkg insert for PO/IV dose conversions; do not cut/crush/chew tab

renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class B: give usual dose qd; Child-Pugh Class C: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.