Select a medication above to begin.
Zepatier
elbasvir/ grazoprevir
Black Box Warnings .
Hepatitis B Reactivation
test all pts for currrent or prior HBV infection before starting tx; reported in HCV/HBV co-infected pts on or those who completed HCV direct-acting antiviral tx who were not on anti-HBV tx, incl. cases resulting in fulminant hepatitis, hepatic failure, and death; screen all pts for HBV infection before initial tx; monitor for hepatitis flare or s/sx HBV reactivation during tx and after D/C; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 50 mg/100 mg
hepatitis C infection, chronic
- [genotype 1]
- Dose: 1 tab PO qd x12wk or x16wk; Info: screen for NS5A polymorphism in pts w/ genotype 1a; duration depends on genotype subtype, prior tx; may give w/ ribavirin if tx-experienced; refer to AASLD/IDSA hepatitis C guidelines
- [genotype 3 (off-label)]
- Dose: 1 tab PO qd w/ sofosbuvir x12wk; Info: for tx-experienced pts w/ compensated cirrhosis; refer to AASLD/IDSA hepatitis C guidelines
- [genotype 4]
- Dose: 1 tab PO qd x12wk; Info: duration depends on prior tx; refer to AASLD/IDSA hepatitis C guidelines
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B or C: contraindicated
Peds Dosing .
- Dosage forms: TAB: 50 mg/100 mg
chronic hepatitis C infection, genotype 1
- [12 yo and older, >30 kg]
- Dose: 1 tab PO qd x12wk or x16wk; Info: screen for NS5A polymorphism in pts w/ genotype 1a; duration depends on genotype subtype, prior tx; may give w/ ribavirin if tx-experienced
chronic hepatitis C infection, genotype 4
- [12 yo and older, >30 kg]
- Dose: 1 tab PO qd x12wk or x16wk; Info: duration depends on prior tx; may give w/ ribavirin if tx-experienced
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B or C: contraindicated