Select a medication above to begin.
Descovy
emtricitabine/ tenofovir alafenamide
Black Box Warnings .
Hepatitis B Exacerbation
severe acute HBV exacerbations in HBV/HIV co-infected pts when D/C emtricitabine or tenofovir; monitor hepatic fxn closely for at least several months in HBV/HIV co-infected pts who D/C emtricitabine/tenofovir alafenamide; initiate anti-HBV tx if needed
Drug Resistance Risk In HIV Pre-Exposure Prophylaxis Use
only prescribe for pre-exposure prophylaxis use in HIV-negative pts; confirm HIV status immediately before tx, then q3mo; drug-resistant HIV variants identified with emtricitabine/tenofovir disoproxil use following undetected acute HIV infection; do not start in pts w/ acute HIV infection s/sx unless HIV-negative status confirmed
Adult Dosing .
Dosage forms: TAB: 120 mg/15 mg, 200 mg/25 mg
HIV infection
- [200 mg/25 mg PO qd]
HIV pre-exposure prophylaxis
- [200 mg/25 mg PO qd]
- Info: not for pts at risk from receptive vaginal sex; check HIV status before tx start and q3mo or upon diagnosis of other sexually transmitted infections
HIV post-exposure prophylaxis (off-label)
- [200 mg/25 mg PO qd]
- Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables
hepatitis B infection, chronic (off-label)
- [200 mg/25 mg PO qd]
renal dosing
- [see below]
- CrCl <30: avoid use
- HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined; Info: not for pts on concomitant protease inhibitors requiring ritonavir or cobicistat boosting
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Peds Dosing .
- Dosage forms: TAB: 120 mg/15 mg, 200 mg/25 mg
HIV infection
- [14-24 kg]
- Dose: 120 mg/15 mg PO qd; Info: not for pts on concomitant protease inhibitors requiring ritonavir or cobicistat boosting
- [25-34 kg]
- Dose: 200 mg/25 mg PO qd; Info: not for pts on concomitant protease inhibitors requiring ritonavir or cobicistat boosting
- [>35 kg]
- Dose: 200 mg/25 mg PO qd
HIV pre-exposure prophylaxis
- [adolescents, >35 kg]
- Dose: 200 mg/25 mg PO qd; Info: not for pts at risk from receptive vaginal sex; check HIV status before tx start and q3mo or upon diagnosis of other sexually transmitted infections
renal dosing
- [see below]
- CrCl <30: avoid use
- HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined