Venclexta

Adult Dosing .

Dosage forms:  TAB: 10 mg, 50 mg, 100 mg; convenience pack

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

[convenience pack components]

Info: 4-wk starting pack contains 10 mg tab x14 and 50 mg tab x7 and 100 mg tab x21

AML, newly diagnosed

[combo w/ azacitidine or decitabine]

Dose: 100 mg PO qd on day 1, then 200 mg PO qd on day 2, then 400 mg PO qd on day 3 as part of ramp-up dosing schedule, then 400 mg PO qd starting day 4; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose; give w/ food; do not cut/crush/chew tab

[combo w/ low-dose cytarabine]

Dose: 100 mg PO qd on day 1, then 200 mg PO qd on day 2, then 400 mg PO qd on day 3, then 600 mg PO qd on day 4 as part of ramp-up dosing schedule, then 600 mg PO qd starting day 5; Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; cytoreduction may be required if WBC >25,000 prior to 1st dose; give w/ food; do not cut/crush/chew tab

CLL/SLL

[monotherapy]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6; Info: give w/ food; do not cut/crush/chew tab

[combo w/ obinutuzumab]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6 until wk 45; Start: on cycle 1 day 22 of obinutuzumab; Info: give w/ food; do not cut/crush/chew tab

[combo w/ rituximab]

Dose: 20 mg PO qd on wk 1, then 50 mg PO qd on wk 2, then 100 mg PO qd on wk 3, then 200 mg PO qd on wk 4, then 400 mg PO qd on wk 5 as part of ramp-up dosing schedule, then 400 mg PO qd starting wk 6 until wk 109; Info: start rituximab on wk 6 after receiving venetoclax 400 mg/day dose x7 days and cont. venetoclax tx x24mo after initiating rituximab; give w/ food; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: decr. usual dose by 50%

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.