Briviact

Adult Dosing .

Dosage forms:  TAB: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg; SOL: 10 mg per mL; INJ: various

partial seizures

[25-100 mg PO/IV bid]

Start: 50 mg PO/IV bid; Max: 200 mg/day; Info: for monotherapy and adjunct tx; consider lower dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab; taper dose gradually to D/C

renal dosing

[see below]

renal impairment: no adjustment; ESRD: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: start 25 mg bid, max 150 mg/day

Peds Dosing .

Dosage forms:  TAB: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg; SOL: 10 mg per mL; INJ: various

partial seizures

[1 mo-15 yo, <11 kg]

Dose: 0.75-3 mg/kg/dose PO/IV bid; Start: 0.75-1.5 mg/kg/dose PO/IV bid; Max: 6 mg/kg/day; Info: for monotherapy and adjunct tx; consider lower dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab; taper dose gradually to D/C

[1 mo-15 yo, 11-20 kg]

Dose: 0.5-2.5 mg/kg/dose PO/IV bid; Start: 0.5-1.25 mg/kg/dose PO/IV bid; Max: 5 mg/kg/day; Info: for monotherapy and adjunct tx; consider lower dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab; taper dose gradually to D/C

[1 mo-15 yo, 20-50 kg]

Dose: 0.5-2 mg/kg/dose PO/IV bid; Start: 0.5-1 mg/kg/dose PO/IV bid; Max: 4 mg/kg/day; Info: for monotherapy and adjunct tx; consider lower dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab; taper dose gradually to D/C

[1 mo-15 yo, >50 kg]

Dose: 25-100 mg PO/IV bid; Start: 25-50 mg PO/IV bid; Max: 200 mg/day; Info: for monotherapy and adjunct tx; consider lower dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab; taper dose gradually to D/C

[16 yo and older]

Dose: 25-100 mg PO/IV bid; Start: 50 mg PO/IV bid; Max: 200 mg/day; Info: for monotherapy and adjunct tx; consider lower dose in CYP2C19 poor metabolizers; do not cut/crush/chew tab; taper dose gradually to D/C

renal dosing

[see below]

renal impairment: no adjustment; ESRD: not defined

HD/PD: not defined

hepatic dosing

[<11 kg]

hepatic impairment: start 0.75 mg/kg/dose bid, max 4.5 mg/kg/day

[11-20 kg]

hepatic impairment: start 0.5 mg/kg/dose bid, max 4 mg/kg/day

[20-50 kg]

hepatic impairment: start 0.5 mg/kg/dose bid, max 3 mg/kg/day

[>50 kg]

hepatic impairment: start 25 mg bid, max 150 mg/day