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Virazole
ribavirin inhaled
Black Box Warnings .
Appropriate Use
not indicated for adult pts; use only in mechanically ventilated pts by physicians and staff familiar w/ ventilator type and inhaled ribavirin admin; accumulation of drug precipitate may result in mechanical ventilator dysfxn and associated incr. pulmonary pressures
Respiratory Fxn in Infants
inhaled ribavirin use in infants associated w/ sudden resp. fxn deterioration; monitor resp. fxn during tx; D/C tx if sudden deterioration; may restart tx w/ extreme caution, continuous monitoring, and possible bronchodilator admin.
Teratogenicity
risk of teratogenicity and embryo-fetal death based on animal data w/ oral form
Adult Dosing .
Dosage forms: NEB: 20 mg per mL
RSV infection, allogeneic HSCT pts (off-label)
- [6 g continuous NEB over 18h qd x7-10 days]
- Alt: 2 g NEB over 2h q8h x7-10 days; Info: confirm RSV antigen status w/in 24h of tx start; use alone in Small Particle Aerosol Generator (SPAG-2) nebulizer
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: NEB: 20 mg per mL
RSV infection, severe
- [infants/young children]
- Dose: 6 g continuous NEB over 12-18h qd x3-7 days; Info: confirm RSV antigen status w/in 24h of tx start; use alone in Small Particle Aerosol Generator (SPAG-2) nebulizer
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]