Afstyla

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 20-40%

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 30-60%

[bleeding episode, major or life-threatening]

Dose: individualize dose IV q8-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 60-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop, then repeat dose IV q24h for at least 1 day until healing complete; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 30-60%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then repeat dose IV q8-24h post-op until healing complete, then continue for at least another 7 days; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 80-100% until healing complete, then 30-60% until tx D/C

[routine bleeding prophylaxis]

Dose: 20-50 units/kg/dose IV 2-3x/wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 20-40%

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 30-60%

[bleeding episode, major or life-threatening]

Dose: individualize dose IV q8-24h until hemostasis; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 60-100%

[bleeding prophylaxis, minor surgery]

Dose: individualize dose IV x1 preop, then repeat dose IV q24h for at least 1 day until healing complete; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 30-60%

[bleeding prophylaxis, major surgery]

Dose: individualize dose IV x1 preop, then repeat dose IV q8-24h post-op until healing complete, then continue for at least another 7 days; Info: estimated dose (units) is [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level is 80-100% until healing complete, then 30-60% until tx D/C

[routine bleeding prophylaxis, <12 yo]

Dose: 30-50 units/kg/dose IV 2-3x/wk; Info: more frequent or higher doses may be required

[routine bleeding prophylaxis, 12 yo and older]

Dose: 20-50 units/kg/dose IV 2-3x/wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]