Photrexa

Adult Dosing .

Dosage forms:  SOL: 0.146%

Special Note

[formulation clarification]

Info: viscous form contains riboflavin in dextran solution; reserve non-viscous form for corneal thickening

progressive keratoconus

[viscous formulation]

Dose: 1 gtt in eye(s) q2min x30min, then exam for yellow flare; if no flare, cont. 1 gtt in eye(s) q2min x2-3 doses and recheck; repeat until yellow flare observed, then measure corneal thickness; if corneal thickness at least 400 microns, start irradiation and cont. 1 gtt in eye(s) q2min x30min; if corneal thickness <400 microns, apply non-viscous form q5-10sec until thickness at least 400 microns, then start irradiation and apply viscous form 1 gtt in eye(s) q2min x30min; Info: see pkg insert

corneal ectasia, post-surgical

[viscous formulation]

Dose: 1 gtt in eye(s) q2min x30min, then exam for yellow flare; if no flare, cont. 1 gtt in eye(s) q2min x2-3 doses and recheck; repeat until yellow flare observed, then measure corneal thickness; if corneal thickness at least 400 microns, start irradiation and cont. 1 gtt in eye(s) q2min x30min; if corneal thickness <400 microns, apply non-viscous form q5-10sec until thickness at least 400 microns, then start irradiation and apply viscous form 1 gtt in eye(s) q2min x30min; Info: see pkg insert

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  SOL: 0.146%

Special Note

[formulation clarification]

Info: viscous form contains riboflavin in dextran solution; reserve non-viscous form for corneal thickening

progressive keratoconus

[viscous formulation, 14 yo and older]

Dose: 1 gtt in eye(s) q2min x30min, then exam for yellow flare; if no flare, cont. 1 gtt in eye(s) q2min x2-3 doses and recheck; repeat until yellow flare observed, then measure corneal thickness; if corneal thickness at least 400 microns, start irradiation and cont. 1 gtt in eye(s) q2min x30min; if corneal thickness <400 microns, apply non-viscous form q5-10sec until thickness at least 400 microns, then start irradiation and apply viscous form 1 gtt in eye(s) q2min x30min; Info: see pkg insert

corneal ectasia, post-surgical

[viscous formulation, 14 yo and older]

Dose: 1 gtt in eye(s) q2min x30min, then exam for yellow flare; if no flare, cont. 1 gtt in eye(s) q2min x2-3 doses and recheck; repeat until yellow flare observed, then measure corneal thickness; if corneal thickness at least 400 microns, start irradiation and cont. 1 gtt in eye(s) q2min x30min; if corneal thickness <400 microns, apply non-viscous form q5-10sec until thickness at least 400 microns, then start irradiation and apply viscous form 1 gtt in eye(s) q2min x30min; Info: see pkg insert

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]