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ofloxacin
generic
Black Box Warnings .
Disabling, Potentially Irreversible Serious Reactions
fluoroquinolones assoc. with tendinitis/tendon rupture, peripheral neuropathy, and CNS effects that may occur together; tendinitis/tendon rupture may occur during tx or months after tx D/C; incr. tendinitis/tendon rupture risk in all ages; risk further incr. in older pts >60 yo, pts taking corticosteroids, and pts w/ kidney, heart, or lung transplant; D/C immediately and avoid fluoroquinolone use in pts w/ these serious reactions
Avoid in Myasthenia Gravis
fluoroquinolones may exacerbate muscle weakness in pts w/ myasthenia gravis
Reserve Fluoroquinolone Use
for pts w/ no alternative tx options for acute bacterial exacerbation of chronic bronchitis or uncomplicated UTI
Adult Dosing .
Dosage forms: TAB: 200 mg, 300 mg, 400 mg
infections, bacterial
- [200-400 mg PO q12h]
- Info: dose, duration varies w/ infection type, severity
prostatitis
- [300 mg PO q12h x6wk]
UTI, complicated
- [200 mg PO q12h x10 days]
UTI, uncomplicated
- [200 mg PO q12h x3-7 days]
- Info: for pts w/ no alternative tx options; give x3 days if cystitis; refer to IDSA guidelines
leprosy (Hansen dz), multibacillary (off-label)
- [pts who cannot take clofazimine]
- Dose: 400 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 12mo in refractory cases
- [pts who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
leprosy (Hansen dz), paucibacillary (off-label)
- [pts who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
typhoid fever (off-label)
- [400 mg PO bid x7-14 days]
renal dosing
- [see below]
- CrCl 20-50: give usual dose q24h; CrCl <20: give usual dose x1, then give 50% usual dose q24h
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- cirrhosis: max 400 mg/24h
Peds Dosing .
- Dosage forms: TAB: 200 mg, 300 mg, 400 mg
leprosy (Hansen dz), multibacillary (off-label)
- [15 yo and older, pts who cannot take clofazimine]
- Dose: 400 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 12mo in refractory cases
- [15 yo and older, pts who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
leprosy (Hansen dz), paucibacillary (off-label)
- [15 yo and older, pts who cannot take rifampin]
- Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases
typhoid fever (off-label)
- [20 mg/kg/dose PO bid x10 days]
- Max: 400 mg/dose
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance