Dupixent

Adult Dosing .

Dosage forms:  INJ (pen): 200 mg per 1.14 mL, 300 mg per 2 mL; INJ (pre-filled syringe): 200 mg per 1.14 mL, 300 mg per 2 mL

atopic dermatitis, moderate-severe

[300 mg SC every other week]

Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe eosinophilic asthma, maintenance tx

[200 mg SC every other week]

Start: 400 mg SC x1 on day 1, then 200 mg SC every other week; Alt: start 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe PO corticosteroid-dependent asthma, maintenance tx

[300 mg SC every other week]

Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe PO corticosteroid-dependent asthma w/ concurrent moderate-severe atopic dermatitis, maintenance tx

[300 mg SC every other week]

Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe PO corticosteroid-dependent asthma w/ concurrent chronic rhinosinusitis w/ nasal polyps, maintenance tx

[300 mg SC every other week]

Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

chronic rhinosinusitis w/ nasal polyps, maintenance tx

[300 mg SC every other week]

eosinophilic esophagitis

[300 mg SC qwk]

prurigo nodularis

[300 mg SC every other week]

Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

eosinophilic COPD, maintenance tx

[300 mg SC every other week]

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ (pen): 200 mg per 1.14 mL, 300 mg per 2 mL; INJ (pre-filled syringe): 200 mg per 1.14 mL, 300 mg per 2 mL

Special Note

[formulation clarification]

Info: pen form for use in pts 2 yo and older; pre-filled syringe form for use in pts 6 mo and older

atopic dermatitis, moderate-severe

[6 mo-5 yo, 5-14 kg]

Dose: 200 mg SC q4wk

[6 mo-5 yo, 15-29 kg]

Dose: 300 mg SC q4wk

[6-17 yo, 15-29 kg]

Dose: 300 mg SC q4wk; Start: 600 mg SC x1 on day 1, then 300 mg SC q4wk

[6-17 yo, 30-59 kg]

Dose: 200 mg SC every other week; Start: 400 mg SC x1 on day 1, then 200 mg SC every other week

[6-17 yo, >60 kg]

Dose: 300 mg SC every other week; Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe eosinophilic asthma, maintenance tx

[6-11 yo, 15-29 kg]

Dose: 300 mg SC q4wk

[6-11 yo, >30 kg]

Dose: 200 mg SC every other week

[12 yo and older]

Dose: 200 mg SC every other week; Start: 400 mg SC x1 on day 1, then 200 mg SC every other week; Alt: start 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe PO corticosteroid-dependent asthma, maintenance tx

[6-11 yo, 15-29 kg]

Dose: 300 mg SC q4wk

[6-11 yo, >30 kg]

Dose: 200 mg SC every other week

[12 yo and older]

Dose: 300 mg SC every other week; Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

moderate-severe PO corticosteroid-dependent asthma w/ concurrent moderate-severe atopic dermatitis, maintenance tx

[6-11 yo, 15-29 kg]

Dose: 300 mg SC q4wk; Start: 600 mg SC x1 on day 1, then 300 mg SC q4wk

[6-11 yo, 30-59 kg]

Dose: 200 mg SC every other week; Start: 400 mg SC x1 on day 1, then 200 mg SC every other week

[6-11 yo, >60 kg]

Dose: 300 mg SC every other week; Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

[12 yo and older]

Dose: 300 mg SC every other week; Start: 600 mg SC x1 on day 1, then 300 mg SC every other week

chronic rhinosinusitis w/ nasal polyps, maintenance tx

[12 yo and older]

Dose: 300 mg SC every other week

eosinophilic esophagitis

[1 yo and older, 15-29 kg]

Dose: 200 mg SC every other week

[1 yo and older, 30-39 kg]

Dose: 300 mg SC every other week

[1 yo and older, >40 kg]

Dose: 300 mg SC qwk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]