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Ingrezza
valbenazine
Black Box Warnings .
Depression and Suicidality
incr. risk of depression and suicidality in pts w/ Huntington dz, esp. if depression hx or prior suicide attempts or ideation; weigh risk vs. benefit; observe all pts for new or worsening depression, suicidality, or unusual behavior changes; inform pts and caregivers of depression and suicidality risk and instruct to report any concerning behaviors
Adult Dosing .
Dosage forms: CAP: 40 mg, 60 mg, 80 mg; tardive dyskinesia convenience pack; Huntington dz-associated chorea convenience pack
Restricted Distribution in US
- [1-844-647-3992 or www.ingrezzahcp.com for more info]
Special Note
- [tardive dyskinesia convenience pack components]
- Info: 4-wk starter pack contains 40 mg tab x7 and 80 mg tab x21
- [Huntington dz-associated chorea convenience pack components]
- Info: 4-wk starter pack contains 40 mg tab x14 and 60 mg tab x14
tardive dyskinesia
- [80 mg PO qd]
- Start: 40 mg PO qd x1wk, then incr. to 80 mg PO qd; Info: may consider 40-60 mg PO qd based on response and tolerability; give 40 mg PO qd in CYP2D6 poor metabolizers
chorea, Huntington dz-associated
- [80 mg PO qd]
- Start: 40 mg PO qd, then incr. by 20 mg/day q2wk; Info: may consider 40-60 mg PO qd based on response and tolerability; give 40 mg PO qd in CYP2D6 poor metabolizers
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B or C: 40 mg qd
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.