Zejula

Adult Dosing .

Dosage forms:  CAP: 100 mg; TAB: 100 mg, 200 mg, 300 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

ovarian CA, maintenance tx

[first-line tx, <77 kg or Plt <150,000]

Dose: 200 mg PO qd; Start: w/in 12wk of last platinum-based tx; Info: for platinum-sensitive advanced epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap; do not cut/crush/chew tab

[first-line tx, >77 kg and Plt >150,000]

Dose: 300 mg PO qd; Start: w/in 12wk of last platinum-based tx; Info: for platinum-sensitive advanced epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap; do not cut/crush/chew tab

[recurrent dz]

Dose: 300 mg PO qd; Start: w/in 8wk of last platinum-based tx; Info: for platinum-sensitive gBRCA-mutated epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap; do not cut/crush/chew tab

homologous recombination deficiency-positive ovarian CA, advanced

[indication withdrawn in US]

Info: mfr has voluntarily withdrawn this indication in pts who have received 3 or more lines of chemo d/t potential survival detriment

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.5-3x ULN: start 200 mg qd; bilirubin >3x ULN: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.