Syndros

Adult Dosing .

Dosage forms:  SOL: 5 mg per mL

anorexia/weight loss, AIDS-assoc.

[2.1-4.2 mg PO bid]

Start: 2.1 mg PO bid, may incr. by 2.1 mg/day gradually; Max: 16.8 mg/day; Info: give 1h before lunch and dinner; decr. to 2.1 mg PO qpm or qhs if start dose poorly tolerated; consider starting 2.1 mg PO qpm or qhs in elderly pts; taper dose gradually to D/C if prolonged, high-dose use

chemo-related nausea/vomiting, refractory

[4.2 mg/m^2/dose PO x1, then 4.2 mg/m^2/dose PO q2-4h x4-6 doses/day]

Start: 1-3h before chemo; Max: 12.6 mg/m^2/dose x4-6 doses/day; Alt: 2.1-4.2 mg/m^2/dose PO tid-qid; Info: round dose to nearest 0.1 mg; give 1st dose >30min before meal, then give consistently w/ or w/o food; may adjust dose in 2.1 mg/m^2/dose increments; consider starting 2.1 mg/m^2/dose PO qd 1-3h before chemo in elderly pts; consider decr. to 2.1 mg/dose PO qd 1-3h before chemo if poorly tolerated; taper dose gradually to D/C if prolonged, high-dose use; search 'CINV' for epocrates Chemo-Induced Nausea & Vomiting in Adults decision tool

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.