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Vosevi
sofosbuvir/ velpatasvir/ voxilaprevir
Black Box Warnings .
Hepatitis B Reactivation
test all pts for currrent or prior HBV infection before starting tx; reported in HCV/HBV co-infected pts on or those who completed HCV direct-acting antiviral tx who were not on anti-HBV tx, incl. cases resulting in fulminant hepatitis, hepatic failure, and death; screen all pts for HBV infection before initial tx; monitor for hepatitis flare or s/sx HBV reactivation during tx and after D/C; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 400 mg/100 mg/100 mg
chronic hepatitis C infection, genotypes 1-6
- [pts w/o cirrhosis or w/ compensated cirrhosis]
- Dose: 1 tab PO qd x12wk; Info: may give w/ ribavirin; may give x24wk; refer to AASLD/IDSA hepatitis C guidelines; give w/ food
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class B or C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.