Select a medication above to begin.
Mavyret
glecaprevir/ pibrentasvir
Black Box Warnings .
Hepatitis B Reactivation
test all pts for currrent or prior HBV infection before starting tx; reported in HCV/HBV co-infected pts on or those who completed HCV direct-acting antiviral tx who were not on anti-HBV tx, incl. cases resulting in fulminant hepatitis, hepatic failure, and death; screen all pts for HBV infection before initial tx; monitor for hepatitis flare or s/sx HBV reactivation during tx and after D/C; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 100 mg/40 mg; PELLET: 50 mg/20 mg per pkt
chronic hepatitis C infection, genotypes 1-6
- [tx-naive pts]
- Dose: 300 mg/120 mg PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-experienced pts]
- Dose: 300 mg/120 mg PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin if glecaprevir/pibrentasvir or sofosbuvir/velpatasvir/voxilaprevir tx failure; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class B or C: contraindicated
Peds Dosing .
- Dosage forms: TAB: 100 mg/40 mg; PELLET: 50 mg/20 mg per pkt
chronic hepatitis C infection, genotypes 1-6
- [tx-naive pts, 3-11 yo, <20 kg]
- Dose: 150 mg/60 mg pellets PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-naive pts, 3-11 yo, 20-29 kg]
- Dose: 200 mg/80 mg pellets PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-naive pts, 3-11 yo, 30-44 kg]
- Dose: 250 mg/100 mg pellets PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-naive pts, 3-11 yo, >45 kg]
- Dose: 300 mg/120 mg PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-naive pts, 12 yo and older]
- Dose: 300 mg/120 mg PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-experienced pts, 3-11 yo, <20 kg]
- Dose: 150 mg/60 mg pellets PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-experienced pts, 3-11 yo, 20-29 kg]
- Dose: 200 mg/80 mg pellets PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-experienced pts, 3-11 yo, 30-44 kg]
- Dose: 250 mg/100 mg pellets PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-experienced pts, 3-11 yo, >45 kg]
- Dose: 300 mg/120 mg PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
- [tx-experienced pts, 12 yo and older]
- Dose: 300 mg/120 mg PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class B or C: contraindicated