Verzenio

Adult Dosing .

Dosage forms:  TAB: 50 mg, 100 mg, 150 mg, 200 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

hormone receptor-positive HER2-negative breast CA, early

[adjuvant tx, combo w/ tamoxifen or aromatase inhibitor]

Dose: 150 mg PO bid x2y; Info: for pts w/ node-positive early dz at high risk of recurrence; use w/ LHRH agonist per standard practice in pre/perimenopausal pts if used in combo w/ aromatase inhibitor; do not cut/crush/chew tab

hormone receptor-positive HER2-negative breast CA, advanced or metastatic

[first-line tx, combo w/ aromatase inhibitor]

Dose: 150 mg PO bid; Info: use w/ LHRH agonist per standard practice in pre/perimenopausal pts; do not cut/crush/chew tab

[progressive dz, combo w/ fulvestrant]

Dose: 150 mg PO bid; Info: use w/ LHRH agonist per standard practice in pre/perimenopausal pts; do not cut/crush/chew tab

[progressive dz, monotherapy]

Dose: 200 mg PO bid; Info: do not cut/crush/chew tab

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[adjust dose frequency]

Child-Pugh Class C: give usual dose qd

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.