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Baxdela
delafloxacin
Black Box Warnings .
Disabling, Potentially Irreversible Serious Reactions
fluoroquinolones assoc. with tendinitis/tendon rupture, peripheral neuropathy, and CNS effects that may occur together; tendinitis/tendon rupture may occur during tx or months after tx D/C; incr. tendinitis/tendon rupture risk in all ages; risk further incr. in older pts >60 yo, pts taking corticosteroids, and pts w/ kidney, heart, or lung transplant; D/C immediately and avoid fluoroquinolone use in pts w/ these serious reactions
Avoid in Myasthenia Gravis
fluoroquinolones may exacerbate muscle weakness in pts w/ myasthenia gravis
Adult Dosing .
Dosage forms: TAB: 450 mg; INJ: various
skin/skin structure infections, bacterial
- [450 mg PO q12h x5-14 days]
- Alt: 300 mg IV q12h x5-14 days; Info: may switch to 450 mg PO q12h when possible to complete course
pneumonia, community-acquired
- [450 mg PO q12h x5-10 days]
- Alt: 300 mg IV q12h x5-10 days; Info: may switch to 450 mg PO q12h when possible to complete course
renal dosing
- [PO route]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
- [IV route]
- eGFR 15-29: 200 mg IV q12h, may switch to 450 mg PO q12h when possible to complete course; eGFR <15: avoid use; Info: risk of IV vehicle accumulation
- HD/PD: avoid use; Info: risk of IV vehicle accumulation
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.