tetracycline

Adult Dosing .

Dosage forms:  CAP: 250 mg, 500 mg

infections, bacterial

[1-2 g/day PO divided bid-qid]

Info: duration varies w/ infection type, severity; give w/ adequate fluid at least 1h before or 2h after meals

severe acne vulgaris, adjunct tx

[250-500 mg PO qd]

Start: 250-500 mg PO bid x2-3mo; Info: give w/ adequate fluid at least 1h before or 2h after meals

syphilis

[primary, secondary, or latent <1y]

Dose: 500 mg PO qid x14 days; Info: for pts w/ hypersensitivity to PCN; not 1st-line agent; give w/ adequate fluid at least 1h before or 2h after meals

[latent >1y or unknown duration]

Dose: 500 mg PO qid x28 days; Info: for pts w/ hypersensitivity to PCN; not 1st-line agent; give w/ adequate fluid at least 1h before or 2h after meals

H. pylori infection (off-label)

[500 mg PO qid x14 days]

Info: part of multi-drug regimen; give w/ adequate fluid at least 1h before or 2h after meals; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

malaria tx, uncomplicated (off-label)

[250 mg PO qid x7 days]

Info: give w/ quinine sulfate; give w/ adequate fluid at least 1h before or 2h after meals; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

renal dosing

[see below]

renal impairment: consider decr. usual dose and/or frequency

HD: give usual dose q24h; no supplement after dialysis; PD: give usual dose q24h; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 250 mg, 500 mg

infections, bacterial

[>8 yo]

Dose: 25-50 mg/kg/day PO divided qid; Max: 2000 mg/day; Info: duration varies w/ infection type, severity; give w/ adequate fluid at least 1h before or 2h after meals

severe acne vulgaris, adjunct tx

[>8 yo]

Dose: 250-500 mg PO qd; Start: 250-500 mg PO bid x2-3mo; Info: give w/ adequate fluid at least 1h before or 2h after meals

syphilis

[primary, secondary, or latent <1y, adolescents]

Dose: 500 mg PO qid x14 days; Info: for pts w/ hypersensitivity to PCN; not 1st-line agent; give w/ adequate fluid at least 1h before or 2h after meals

[latent >1y or unknown duration, adolescents]

Dose: 500 mg PO qid x28 days; Info: for pts w/ hypersensitivity to PCN; not 1st-line agent; give w/ adequate fluid at least 1h before or 2h after meals

malaria tx, uncomplicated (off-label)

[25 mg/kg/day PO divided qid x7 days]

Max: 1000 mg/day; Info: give w/ quinine sulfate; give w/ adequate fluid at least 1h before or 2h after meals; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

renal dosing

[acne vulgaris]

renal impairment: consider decr. usual dose and/or frequency

HD/PD: not defined, consider adult renal dosing for guidance

[all other indications]

eGFR 50-80: give usual divided dose q8-12h; eGFR 10-50: give usual divided dose q12-24h; eGFR <10: give usual divided dose q24h

HD/PD: not defined, consider adult renal dosing for guidance

hepatic dosing

[not defined]