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Black Box Warnings .
Hepatitis B Exacerbation
severe acute HBV exacerbations in HBV/HIV co-infected pts when lamivudine or tenofovir D/C; monitor hepatic fxn closely for at least several months in HBV/HIV co-infected pts who D/C efavirenz/lamivudine/tenofovir; initiate anti-HBV tx if needed
Adult Dosing .
Dosage forms: TAB: 400 mg/300 mg/300 mg
HIV infection
- [1 tab PO qhs]
- Info: give on empty stomach
renal dosing
- [see below]
- CrCl <50: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD/PD: avoid use, dose adjustment not possible w/ fixed-dose combo
hepatic dosing
- [see below]
- moderate-severe impairment: avoid use
Peds Dosing .
- Dosage forms: TAB: 400 mg/300 mg/300 mg
HIV infection
- [>35 kg]
- Dose: 1 tab PO qhs; Info: give on empty stomach
renal dosing
- [see below]
- CrCl <50: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD/PD: avoid use, dose adjustment not possible w/ fixed-dose combo
hepatic dosing
- [see below]
- moderate-severe impairment: avoid use