Admelog

Adult Dosing .

Dosage forms:  INJ (SoloStar U-100 pen): 100 units per mL; INJ (U-100 vial): 100 units per mL

Special Note

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[intermittent SC injection]

Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); give <15min before or immediately after meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

[continuous SC infusion]

Dose: individualize dose via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

[IV route]

Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum

diabetes mellitus, type 2

[intermittent SC injection]

Dose: individualize dose SC bid-qid; Start: 4 units SC qd or 10% of basal insulin dose SC qd, may incr. dose by 1-2 units or 10-15% 2x/wk; Info: give <15min before or immediately after meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

[continuous SC infusion]

Dose: individualize dose via continuous SC infusion pump; Info: dose adjustment may be needed during pregnancy and/or immed. postpartum; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

[IV route]

Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum

diabetic ketoacidosis, mild-moderate uncomplicated (off-label)

[q1h dosing regimen]

Dose: 0.1 units/kg/dose SC q1h; Start: 0.1 units/kg/dose SC x1; Info: when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/dose SC q1h and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; refer to institutional protocol

[q2h dosing regimen]

Dose: 0.2 units/kg/dose SC q2h; Start: 0.1 units/kg/dose SC x1; Info: when blood glucose <250 mg/dL, decr. dose to 0.1 units/kg/dose SC q2h and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; refer to institutional protocol

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD/PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ (SoloStar U-100 pen): 100 units per mL; INJ (U-100 vial): 100 units per mL

Special Note

[additional info]

Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility

diabetes mellitus, type 1

[intermittent SC injection, 3 yo and older]

Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; give <15min before or immediately after meals; use w/ intermediate-acting or long-acting insulin; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

[continuous SC infusion, 3 yo and older]

Dose: individualize dose via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

diabetes mellitus, type 2

[intermittent SC injection]

Dose: individualize dose SC bid-qid; Info: give <15min before or immediately after meals; use w/ intermediate-acting or long-acting insulin; onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

[continuous SC infusion]

Dose: individualize dose via continuous SC infusion pump; Info: onset <0.5h, peak 0.83h, duration <6h (rapid-acting insulin)

diabetic ketoacidosis, mild-moderate uncomplicated (off-label)

[0.15 units/kg/dose SC q2h]

Start: 1h after initial fluid tx; Info: add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; may decr. dose to 0.1 units/kg/dose SC q2h if blood glucose continues to decr. by >90 mg/dL/h; maintain blood glucose at 200 mg/dL until DKA resolves; refer to institutional protocol

renal dosing

[see below]

renal impairment: consider decr. usual start dose

HD/PD: consider decr. usual start dose; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised