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Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 50 mg/12.5 mg, 100 mg/12.5 mg, 100 mg/25 mg
HTN
- [1 tab PO qd]
- Start: 50 mg/12.5 mg PO qd if on HCTZ 25 mg/day or losartan 50 mg/day or as initial tx for severe HTN; 100 mg/12.5 mg PO qd if on losartan 100 mg/day; may incr. to 100 mg/25 mg PO qd after 3wk if inadequate response; Max: 100 mg/25 mg/day
stroke prevention
- [1 tab PO qd]
- Start: 50 mg/12.5 mg PO qd if on losartan 50 mg/day, may incr. to 100 mg/12.5 mg PO qd, then may incr. to 100 mg/25 mg PO qd if needed; Max: 100 mg/25 mg/day; Info: for pts w/ HTN and LVH; possibly ineffective in Black pts; not for initial tx
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl 10-30: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: avoid use as initial tx, lower losartan dose not possible w/ fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.