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Nocdurna
desmopressin
Black Box Warnings .
Hyponatremia
severe hyponatremia may be life-threatening, leading to seizures, coma, respiratory arrest, or death; contraindicated in pts w/ severe hyponatremia risk incl. excessive fluid intake, fluid/electrolyte imbalances, or concurrent loop diuretics or systemic/inhaled glucocorticoids; ensure normal serum Na before starting or resuming tx; monitor Na w/in 7 days and x1mo after tx start, then periodically or more frequently in pts 65 yo and older or if hyponatremia risk; consider temporarily or permanently D/C if hyponatremia occurs
Adult Dosing .
Dosage forms: SL TAB: 27.7 mcg, 55.3 mcg
nocturia, nocturnal polyuria-related
- [female pts]
- Dose: 27.7 mcg SL qhs; Info: for pts who awaken at least 2x per night to void; give 60min before bedtime; do not give w/ water; restrict fluid intake at least 1h before and until 8h after admin.
- [male pts]
- Dose: 55.3 mcg SL qhs; Info: for pts who awaken at least 2x per night to void; give 60min before bedtime; do not give w/ water; restrict fluid intake at least 1h before and until 8h after admin.
renal dosing
- [see below]
- eGFR <50: contraindicated
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.