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Aristada Initio
aripiprazole lauroxil
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly pts on antipsychotic tx for dementia-related psychosis; most deaths due to cardiovascular or infectious events
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 675 mg per 2.4 mL
Special Note
- [formulation clarification]
- Info: Aristada Initio not interchangeable w/ Aristada due to different pharmacokinetic profiles
schizophrenia
- [675 mg IM x1]
- Info: for pts stable on PO aripiprazole; give w/ aripiprazole 30 mg PO x1 and 1st dose of Aristada; may give Aristada on same day or up to 10 days after Aristada Initio admin; see pkg insert for missed dose recommendations; avoid use in CYP2D6 poor metabolizers, dose adjustment not possible w/ Aristada Initio
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.