Select a medication above to begin.
belladonna/ opium rectal
generic
Black Box Warnings .
Appropriate Use
should only be prescribed by healthcare professionals knowledgeable about opioid use and how to mitigate assoc. risks; reserve opioid analgesics for pts w/ inadequate tx alternatives; proper dosing and titration essential to decr. resp. depression risk
Addiction, Abuse, and Misuse
Schedule II controlled substance combination containing an opioid agonist w/ risk of addiction, abuse, and misuse, which can lead to overdose and death; assess opioid abuse or addiction risk prior to prescribing; regularly reassess all pts for misuse, abuse, and addiction
Respiratory Depression
serious, life-threatening, or fatal cases may occur even w/ recommended use, esp. during tx start or after dose incr; to decr. risk, initiate and titrate dose appropriately
Accidental Exposure
accidental exposure to even one dose, esp. in children, can result in fatal opium overdose
Risks from Concomitant Use w/ Benzodiazepines, CNS Depressants
concomitant opioid use w/ benzodiazepines or other CNS depressants, incl. alcohol, may result in profound sedation, resp. depression, coma, and death; reserve concomitant use for pts w/ inadequate alternative tx options
Neonatal Opioid Withdrawal Syndrome
extended use in pregnant pts can lead to potentially life-threatening neonatal opioid withdrawal syndrome; advise pregnant pts of risks and ensure tx by neonatology experts avail. at delivery if extended opioid use required
Adult Dosing .
Dosage forms: SUPP: 16.2 mg/30 mg, 16.2 mg/60 mg
Special Note
- [prescribing info]
- Info: consider prescribing naloxone if risk of opioid overdose or accidental exposure
ureteral spasm-assoc. pain, mod-severe
- [1 supp PR qd-bid]
- Max: 4 supp/24h; Info: use lowest effective dose, shortest effective tx duration; titrate gradually to D/C
renal dosing
- [see below]
- severe renal dz: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- severe hepatic dz: contraindicated
Peds Dosing .
- Dosage forms: SUPP: 16.2 mg/30 mg, 16.2 mg/60 mg
Special Note
- [prescribing info]
- Info: consider prescribing naloxone if risk of opioid overdose or accidental exposure
ureteral spasm-assoc. pain, mod-severe
- [>12 yo]
- Dose: 1 supp PR qd-bid; Max: 4 supp/24h; Info: use lowest effective dose, shortest effective tx duration; titrate gradually to D/C
renal dosing
- [see below]
- severe renal dz: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- severe hepatic dz: contraindicated