Glyrx

Adult Dosing .

Dosage forms:  INJ: 0.2 mg per mL

anesthesia adjunct

[preop]

Dose: 0.004 mg/kg/dose IM x1; Start: 30-60min before anesthesia; Info: for reduction of secretions

[intraop]

Dose: 0.1 mg IV q2-3min prn; Info: for reversal of bradycardia, vagal reflexes

neuromuscular blockade reversal adjunct

[0.2 mg IV for each 1 mg neostigmine or 5 mg pyridostigmine dose]

Info: for reversal of muscarinic effects of cholinergic agents

PUD, adjunct tx

[0.1-0.2 mg IM/IV tid-qid]

Max: 0.8 mg/day; Info: space doses 4h apart

renal dosing

[see below]

renal failure: consider decr. usual dose

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose

Peds Dosing .

Dosage forms:  INJ: 0.2 mg per mL

anesthesia adjunct

[preop, <2 yo]

Dose: 0.004-0.009 mg/kg/dose IM x1; Start: 30-60min before anesthesia; Info: for reduction of secretions

[preop, 2 yo and older]

Dose: 0.004 mg/kg/dose IM x1; Start: 30-60min before anesthesia; Info: for reduction of secretions

[intraop]

Dose: 0.004 mg/kg/dose IV q2-3min prn; Max: 0.1 mg/dose; Info: for reversal of bradycardia, vagal reflexes

neuromuscular blockade reversal adjunct

[0.2 mg IV for each 1 mg neostigmine or 5 mg pyridostigmine dose]

Info: for reversal of muscarinic effects of cholinergic agents

renal dosing

[see below]

renal failure: consider decr. usual dose

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose