Nuzyra

Adult Dosing .

Dosage forms:  TAB: 150 mg; INJ: various

Special Note

[dosing clarification]

Info: give tab at least 2h before and 4h after meals/beverages; give tab at least 4h before and 4h after dairy products or multivitamins

pneumonia, community-acquired bacterial

[PO route]

Dose: 300 mg PO qd x7-14 days total; Start: 300 mg PO bid x2 doses

[IV route]

Dose: 100 mg IV q24h x7-14 days total; Start: 200 mg IV x1 or 100 mg IV q12h x2 doses; Info: switch to PO regimen ASAP to complete course

skin/skin structure infections, acute bacterial

[PO route]

Dose: 300 mg PO qd x7-14 days total; Start: 450 mg PO qd x2 doses

[IV route]

Dose: 100 mg IV q24h x7-14 days total; Start: 200 mg IV x1 or 100 mg IV q12h x2 doses; Info: switch to PO regimen ASAP to complete course

anthrax (off-label)

[systemic]

Dose: 100 mg IV q24h for at least 2wk; Start: 200 mg IV x1; Info: not 1st-line agent; part of multi-drug regimen; switch to PO abx x60 days total if aerosol exposure

[cutaneous]

Dose: 300 mg PO q24h x7-10 days total; Start: 450 mg PO q12h x2 days; Info: for non-systemic infection; not 1st-line agent; give abx x60 days total if aerosol exposure

[post-exposure prophylaxis]

Dose: 300 mg PO q24h; Start: 450 mg PO q24h x2 days; Info: not 1st-line agent; give x7 days total if nonaerosol exposure; give x60 days total in combo w/ anthrax vaccine if aerosol exposure; may give x42 days or x14 days total after complete vaccine series in immunocompetent pts 18-65 yo

plague (off-label)

[bubonic]

Dose: 100 mg IV q24h x10-14 days total; Start: 200 mg IV x1; Alt: start 450 mg PO q12h x2 days, then 300 mg PO q24h x10-14 days total; Info: not 1st-line agent

[pharyngeal]

Dose: 100 mg IV q24h x10-14 days total; Start: 200 mg IV x1; Alt: start 450 mg PO q12h x2 days, then 300 mg PO q24h x10-14 days total; Info: not 1st-line agent

[pre-exposure prophylaxis]

Dose: 300 mg PO q24h until 48h after last perceived exposure; Info: not 1st-line agent

[post-exposure prophylaxis]

Dose: 300 mg PO q24h x7 days; Info: not 1st-line agent

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 150 mg; INJ: various

Special Note

[dosing clarification]

Info: give tab at least 2h before and 4h after meals/beverages; give tab at least 4h before and 4h after dairy products or multivitamins

anthrax, systemic (off-label)

[neonates >34 wk gestation]

Dose: 3.85 mg/kg/dose IV q24h x7-10 days; Start: 5.5 mg/kg/dose IV x1; Info: not 1st-line agent; part of multi-drug regimen; switch to PO abx x60 days total if aerosol exposure

anthrax, cutaneous (off-label)

[neonates >34 wk gestation]

Dose: 3.85 mg/kg/dose IV q24h x7-10 days; Start: 5.5 mg/kg/dose IV x1; Info: for non-systemic infection; not 1st-line agent; give abx x60 days total if aerosol exposure

[>8 yo]

Dose: 300 mg PO q24h x7-10 days; Start: 450 mg PO q24h x2 days; Info: for non-systemic infection; not 1st-line agent; give abx x60 days total if aerosol exposure

anthrax, post-exposure prophylaxis (off-label)

[>8 yo]

Dose: 300 mg PO q24h; Start: 450 mg PO q24h x2 days; Info: not 1st-line agent; give x7 days if nonaerosol exposure; give x60 days total in combo w/ anthrax vaccine if aerosol exposure

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]