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Lokelma
sodium zirconium cyclosilicate
Adult Dosing .
Dosage forms: PWDR: 5 g per pkt, 10 g per pkt
hyperkalemia
- [initial tx]
- Dose: 10 g PO tid for up to 48h
- [maintenance tx]
- Dose: 10 g PO qd; Info: may incr. dose by 5 g/day no more frequently than qwk to target serum potassium levels; may decr. dose or D/C tx if serum potassium levels below target; dose range 5 g PO qod to 15 g PO qd
renal dosing
- [see below]
- renal impairment: not defined
- HD: start 5 g qd on non-dialysis days, then may adjust dose based on predialysis potassium level after long interdialytic interval and target serum potassium levels w/ dose range 5-15 g qd on non-dialysis days; no dose on dialysis days; no supplement after dialysis; PD: not defined; Info: consider starting 10 g qd on non-hemodialysis days if K >6.5 mEq/L
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.