Osmolex ER

Adult Dosing .

Dosage forms:  ER TAB: 129 mg, 193 mg, 258 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ other amantadine ER products; do not substitute on a mg to mg basis

Parkinson dz

[129-322 mg PO qam]

Start: 129 mg PO qam, may incr. dose qwk; Max: 322 mg/day; Info: do not cut/crush/chew tab; taper dose gradually to 129 mg/day x1-2wk to D/C

extrapyramidal sx

[129-322 mg PO qam]

Start: 129 mg PO qam, may incr. dose qwk; Max: 322 mg/day; Info: do not cut/crush/chew tab; taper dose gradually to 129 mg/day x1-2wk to D/C

renal dosing

[see below]

CrCl 60-90: give usual dose q24h, may incr. dose >qwk; CrCl 30-59: give usual dose q48h, may incr. dose >q3wk; CrCl 15-29: give usual dose q96h, may incr. dose >q4wk; CrCl <15: contraindicated

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.