Gamifant (emapalumab-lzsg)

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = emapalumab-lzsg

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, concomitant meds to mitigate toxicity, and dosing incl. toxicity-related dose adjustments

primary hemophagocytic lymphohistiocytosis

[1-10 mg/kg/dose IV q3-4 days]

Start: 1 mg/kg/dose IV q3-4 days, adjust dose based on response (see pkg insert); Info: for refractory, recurrent, progressive dz or intolerance w/ conventional tx; use w/ dexamethasone 5-10 mg/m^2/day

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = emapalumab-lzsg

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, concomitant meds to mitigate toxicity, and dosing incl. toxicity-related dose adjustments

primary hemophagocytic lymphohistiocytosis

[1-10 mg/kg/dose IV q3-4 days]

Start: 1 mg/kg/dose IV q3-4 days, adjust dose based on response (see pkg insert); Info: for refractory, recurrent, progressive dz or intolerance w/ conventional tx; use w/ dexamethasone 5-10 mg/m^2/day

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]