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mefloquine hydrochloride
generic
Black Box Warnings .
Neuropsychiatric Adverse Events
do not prescribe for prophylaxis in pts w/ major psychiatric disorders; may cause neuropsychiatric rxns that can persist after D/C tx; if psychiatric or neurologic sx occur during prophylactic use, D/C tx and use alternative
Adult Dosing .
Dosage forms: TAB: 250 mg
Special Note
- [strength clarification]
- Info: 500 mg mefloquine hydrochloride = 456 mg mefloquine base; doses expressed as mefloquine hydrochloride
malaria prophylaxis
- [250 mg PO qwk]
- Start: at least 2wk before exposure; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases
malaria tx, uncomplicated
- [750 mg PO x1, then 500 mg PO 6-12h later x1]
- Info: give w/ food; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 250 mg
Special Note
- [strength clarification]
- Info: 250 mg mefloquine hydrochloride = 228 mg mefloquine base; 15 mg/kg mefloquine hydrochloride = 13.7 mg/kg mefloquine base; doses expressed as mefloquine hydrochloride
malaria prophylaxis
- [<10 kg]
- Dose: 5 mg/kg/dose PO qwk; Start: at least 2wk before exposure; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases
- [10-19 kg]
- Dose: 62.5 mg PO qwk; Start: at least 2wk before exposure; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases
- [20-30 kg]
- Dose: 125 mg PO qwk; Start: at least 2wk before exposure; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases
- [31-45 kg]
- Dose: 187.5 mg PO qwk; Start: at least 2wk before exposure; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases
- [>45 kg]
- Dose: 250 mg PO qwk; Start: at least 2wk before exposure; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases
malaria tx, uncomplicated
- [6 mo and older, >5 kg]
- Dose: 15 mg/kg/dose PO x1, then 10 mg/kg/dose PO 6-12h later x1; Max: 750 mg for initial dose, 500 mg for subsequent doses; Info: give w/ food; repeat full dose if vomiting w/in <30min of dose; repeat 50% dose if vomiting 30-60min after dose; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised