fluvastatin

Adult Dosing .

Dosage forms:  CAP: 20 mg, 40 mg; ER TAB: 80 mg

primary hyperlipidemia

[immediate-release form]

Dose: 20-80 mg/day PO divided qd-bid; Info: may adjust dose q4wk; give qd doses in pm; divide dose bid if on 80 mg/day; do not open cap; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

[extended-release form]

Dose: 80 mg ER PO qd; Info: may be initial tx or substitution for 40 mg IR bid; do not cut/crush/chew ER tab; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

heterozygous familial hypercholesterolemia

[immediate-release form]

Dose: 20-80 mg/day PO divided qd-bid; Info: may adjust dose q4wk; give qd doses in pm; divide dose bid if on 80 mg/day; do not open cap; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

[extended-release form]

Dose: 80 mg ER PO qd; Info: may be initial tx or substitution for 40 mg IR bid; do not cut/crush/chew ER tab; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

cardiovascular event risk reduction

[immediate-release form]

Dose: 20-80 mg/day PO divided qd-bid; Info: may adjust dose q4wk; give qd doses in pm; divide dose bid if on 80 mg/day; do not open cap; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

[extended-release form]

Dose: 80 mg ER PO qd; Info: may be initial tx or substitution for 40 mg IR bid; do not cut/crush/chew ER tab; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

atherosclerotic cardiovascular dz

[immediate-release form]

Dose: 20-80 mg/day PO divided qd-bid; Info: may adjust dose q4wk; give qd doses in pm; divide dose bid if on 80 mg/day; do not open cap; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

[extended-release form]

Dose: 80 mg ER PO qd; Info: may be initial tx or substitution for 40 mg IR bid; do not cut/crush/chew ER tab; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

renal dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised w/ doses >40 mg/day

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

acute hepatic failure or decompensated cirrhosis: contraindicated

Peds Dosing .

Dosage forms:  CAP: 20 mg, 40 mg; ER TAB: 80 mg

heterozygous familial hypercholesterolemia

[immediate-release form, 10 yo and older]

Dose: 20-80 mg/day PO divided qd-bid; Start: 20 mg PO qpm, may incr. dose q6wk; Max: 80 mg/day; Info: give qd doses in pm; divide dose bid if on 80 mg/day; do not open cap

[extended-release form, 10 yo and older]

Dose: 80 mg ER PO qd; Info: use IR form for initial tx; do not cut/crush/chew ER tab

renal dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised w/ doses >40 mg/day

HD: no adjustment; no supplement; PD: not defined

hepatic dosing

[see below]

acute hepatic failure or decompensated cirrhosis: contraindicated